Insertional inactivation of oprD in carbapenem-resistant Pseudomonas aeruginosa strains isolated from burn patients in Tehran, Iran
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چکیده
منابع مشابه
Insertional inactivation of oprD in carbapenem-resistant Pseudomonas aeruginosa strains isolated from burn patients in Tehran, Iran
In this study, we report the insertion sequence ISPpu21 in the oprD porin gene of carbapenem-resistant Pseudomonas aeruginosa isolates from burn patients in Tehran, Iran. Antibiotic susceptibility tests for P. aeruginosa isolates were determined. Production of metallo-β-lactamases (MBLs) and carbapenemase was evaluated and the β-lactamase-encoding and aminoglycoside-modifying enzyme genes were ...
متن کاملevaluation of oprd gene expression in carbapenem-resistant pseudomonas aeruginosa strains isolated from severe burn patients with secondary infection
conclusions the results of this study indicated that a decrease in oprd gene expression is an important mechanism of resistance in carbapenem resistant pseudomonas aeruginosa isolated from severe burn patients with secondary infection. results our study showed that 94.2% of the isolates were resistant to imipenem, 99.5% to meropenem, and all were resistant to ertapenem. the oprd gene expression...
متن کاملISPpu22, a novel insertion sequence in the oprD porin gene of a carbapenem-resistant Pseudomonas aeruginosa isolate from a burn patient in Tehran, Iran
BACKGROUND AND OBJECTIVES The oprD mutation and AmpC overproduction are the main mechanisms of intrinsic resistance to carbapenems such as imipenem and meropenem in Pseudomonas aeruginosa. MATERIALS AND METHODS In this study, we investigated intrinsic resistance to carbapenems including mutation of oprD and AmpC overproduction in a carbapenem-resistant P. aeruginosa isolated from a burn patie...
متن کاملDetection of Mutations of Antimutator Gene pfpI in Pseudomonas aeruginosa Species Isolated from Burn Patients in Tehran, Iran
Introduction: Pseudomonas aeruginosa is an opportunistic pathogen of clinical importance, particularly in immunocompromised and burn patients. This bacterium is becoming resistant to many antibiotics via intrinsic or acquired mechanisms. Mutations in anti-mutator genes, such as pfpI, can be a potential intrinsic mechanism of antibiotic resistance. This study aimed to evaluate the possible effec...
متن کاملPLASMID MEDIATED METAL AND ANTIBIOTIC RESISTANCE IN PSEUDOMONAS AERUGINOSA STRAINS ISOLATED FROM BURN PATIENTS
Pseudomonas aeruginosa is a leading cause of bum infections, and antibiotic- resistant strains of this bacterium are emerging due to extensive application of antibiotics in the bum unit of hospitals. In this study 50 strains of P. aeruginosa were isolated from bum patients infected with this micro-organism in the bum unit of a general hospital in Kerman, Iran over one year [May 1999-ApriI20...
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ژورنال
عنوان ژورنال: New Microbes and New Infections
سال: 2018
ISSN: 2052-2975
DOI: 10.1016/j.nmni.2017.10.013